Dhina Fitiastuti, S.Si., M.Sc.

Email: dhinaf@uii.ac.id

NIK: 166120103

Pangkat/golongan:
Asisten Ahli /Penata Muda Tk.I/ III B

Tempat dan tanggal lahir:
Sleman, 24 April 1990

Alamat rumah:
Jl. Kaliurang km 7 Gg. Mawar no. 44 02/43 Kayen, Condong Catur, Depok, Sleman, Yogyakarta, 55283
HP: 081336414338

Riwayat Pendidikan:
S1  Universitas Gadjah Mada    (S.Si)    Bidang Organic Chemistry
S2  Universitas Gadjah Mada    (M.Sc)    Bidang Organic Chemistry

Mata Kuliah:
1.    Kimia Organik 2
2.    Kimia Organik Sintesis
3.    Fitokimia
4.    Kimia Bahan Alam
5.    Kimia Medisinal
6.    Biokimia
7.    Kimia Kosmetika
8.    Praktikum Kimia Organik
9.    Praktikum Minyak Atsiri
10.    Praktikum Kimia Analitik II
11.    Praktikum Fisika
12.    Praktikum Kromatografi
13.    Praktikum Kimia Bahan Alam

Bidang Keahlian:

Kimia Organik. Sintesis Kimia Organik, Minyak Atsiri.

Topik Riset

Organic synthesis and isolation of natural product chemistry for drugs esp. antimalarial active compounds

Malaria continues to be a main health problem and deadly parasitic disease in the world. The resistance of chloroquine (antimalarial drug) is now extensively spread in some countries, including Indonesia. In Indonesia, the problem has been widely spread in some provinces with the percentage of 10-97%. Therefore, the discovery and development of new effective antimalarial drugs are absolutely required to solve the problems.
Drug discovery is an effort to address the health problems, including malaria. This could be done by isolating the active compounds from medicinal herbs, which are traditionally and empirically employed to cure malaria and by synthesizing the natural product-analog-compounds. Two medicinal plants which have been clinically proven to display antimalaria activity are Garcinia and Calophyllum. The herbs are rich in phenolic secondary metabolite of xanthone (Likhitwitayawuid et al., 1998; Hay et al., 2004; Syamsudin et al., 2008; Naidoo, 2009). This class displays several activities of antimalarial, anticancer, anti-HIV, antioxidant, anti-inflammatory, as well as antibacterial (Ito et al., 1998; Saha et al., 2004; Riscoe et al., 2005). Despite the fact that they possess good antimalaria activity, the isolation only gave very low yield of 0.55% (Hay et al., 2004). Therefore, the synthesis of xanthone is more convenient and advantageous from health, scientific and economic points of view, comparing with the isolation process.
According to the results of QSAR analysis, the most active site of the molecule, i.e. the one which is responsible for the antimalarial activity, could be predicted. The researcher group has already analyzed QSAR properties of xanthone as antimalarial and suggest some potential compound from xanthone derivatives. The synthesized compound will be tested for several antimalarial assays. Moreover, the research group also doing some isolation of secondary metabolites from natural product and also be tested as antimalarial. Furthermore, the synthesized and isolated compound will also be tested as anticancer and antibacterial.

Pengalaman Riset:

1. 2017    Synthesis Of New Potential Antimalarial Drug Active Compound Of C-Prenylated Polyhydroxy Xanthone And In Vitro Assay Against Plasmodium Falciparum    Indonesia Toray Science Foundation (ITSF).
2. 2016    Uji Aktivitas Antimalaria In Vitro dari Fraksi n-Heksana : Etil Asetat (2:1) dan Ekstrak Etanol Rimpang Temu Mangga (Curcuma mangga) terhadap Plasmodium falciparum Galur 3D7    DPPM UII.

Publikasi Ilmiah

1. T. Nuryastuti, S. Setiawati, N. Ngatidjan, M. Mustofa, J. Jumina, D. Fitriastuti and M.I. Darussalam, 2018, Antibiofilm activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide against Candida albicans, Journal de Mycologie Médicale, Article In Press, 1-7.
2. T. S. Julianto, D. Fitriastuti, A. Diniaty, L. Fauzi’ah, W. N. Arlianty, B. W. Febriana and Muhaimin, 2017, The implementation of case study with module-assisted to improve students’ understanding on phytochemistry course, AIP Conference Proceedings, ISBN: 978-0-7354-1603-1, 1911, 020026.
3. D. Fitriastuti, Jumina, and Priatmoko, 2017, Heme polymerization inhibition activity (HPIA) assay of synthesized xanthone derivative as antimalarial compound, AIP Conference Proceedings, ISBN: 978-0-7354-1491-4, 1823, 020120.
4. S. Setiawati, T. Nuryastuti, N. Ngatidjan, M. Mustofa, J. Jumina and D. Fitriastuti, 2017, In vitro antifungal activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide against Candida albicans and its effects on membrane integrity, Mycobiology, 45 (1), 25-30.
5. D. Fitriastuti, Jumina, and Priatmoko, 2016, Synthesis and Characterization of 2, 3, 4-Trihydroxy-5-methyl Xanthone as Antimalarial Compound, Eksakta: Jurnal Ilmu-Ilmu MIPA, 16 (2), 94-102.
6. F. O. Nitbani, Jumina, D. Siswanta, E. N. Sholikhah and D. Fitriastuti, 2016, Synthesis and antibacterial activity of 2-monolaurin, Orient. J. Chem., 32 (6), 3113-3120.
7. D. Fitriastuti, Jumina, Priatmoko dan I. Tahir, 2016, QSAR Study of Antimalaria of Xanthone Derivatives using Multiple Linear Regression Methods, Proceeding of 3rd International Conference On Research, Implementation And Education Of Mathematics And Science, ISBN 978-602-74529-0-9, Yogyakarta.
8. D. Fitriastuti, M. I. D. Mardjan, Jumina, and Mustofa, 2014, Synthesis and Heme polymerization inhibitory activity (HPIA) assay of antiplasmodium of (1)-N-(3,4-dimethoxybenzyl)-1,10-phenanthrolinium bromide from vanillin, Indo. J. Chem., 14 (1), 1–6.

HaKI/Hak Kekayaan Intelektual (Buku/Paten)

1. Proses produksi 3,6-dihidroksisanton dan 3,4,6-trihidroksisanton    2016    Paten    P00201403837

Keynote Speakers

Menjadi pembicara/instruktur dalam berbagai forum ilmiah nasional maupun internasional, baik berupa Seminar, Simposium, Pelatihan, Workshop dan lain sebagainya.

Pembicara Seminar/Pemakalah:
1. 2017    2nd Green and Sustainable Chemistry Conference    Synthesis and Heme Polymerization Inhibition Activity (HPIA) Assay of 1,3,6-Trihydroxyxanthone as Antimalarial Compound    Berlin, Jerman 14-17 Mei 2017
2. 2016    International Conference On Research, Implementation And Education Of Mathematics And Science    QSAR Study Of Antimalaria Of Xanthone Derivatives Using Multiple Linear Regression Methods    Yogyakarta, 16-17 Mei 2016
3. 2013    5th JCS International Symposium on Theoretical Chemistry – QCRI    Synthesis of Antimalarial of 1,10-Phenanthrolinium Bromide Derivatives from Clove and Wintergreen Oils    Nara, Japan, 2013

Pembicara Pengabdian Masyarakat:
1. 2017    “Green School Chemistry” Disampaikan dalam Workshop Guru MGMP Kimia Kabupaten Kebumen 01 April 2017
2. 2016    “Green School Chemistry” Disampaikan dalam Workshop dan Praktikum Kimia Bahan Alam MGMP Kimia Kota Salatiga 13 Desember 2016
3. 2016    “Pemanfaatan Limbah Buah sebagai Bioetanol” Disampaikan dalam forum Workshop Kimia untuk Musyawarah Guru Mata Pelajaran (MGMP) SMA/MA/SMK Kota Samarinda di SMA Islam Bunga Bangsa Samarinda pada tanggal 29 Agustus 2016
4. 2016    “Bahan Tambahan Makanan Alami: Pewarna, Pemanis, Pengawet dan Penyedap rasa” Disampaikan dalam “20 TAHUN PRODI KIMIA: MEMBAWA RAHMATAN LIL ‘ALAMIN” di Desa Kanigoro, Kec. Sapto Sari, Kab. Gunung Kidul, Yogyakarta pada tanggal 23 Agustus 2016

Keanggotaan Profesional

1. Anggota Himpunan Kimia Indonesia (HKI)

2. Member of Royal Society of Chemistry (RSC)

Sertifikasi dan Penghargaan

1. Dosen Pendamping dalam Presentasi Ilmiah dan Penyajian Poster PKM-PE pada PIMNAS ke-30 di Universitas Muslim Indonesia, Makassar    Kemenristekdikti    2017
2. ITSF Research Grant    Indonesia Toray Science Foundation    2017
3. Best Poster Award    International Conference of the Indonesian Chemical Society     2016
4. PARE Long Term Course    Hokkaido University, Japan    2014-2015
5. LPDP Scholarship    Kementerian Keuangan RI    2014
6. Sokendai Asian Winter School    Institute for Molecular Science, Okazaki, Japan    2013
7. PARE Short Course    Hokkaido University, Japan    2013